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Title   진행된 상피성 난소암에서 유도 항암화학요법의 효과 ( Effect of Induction Chemotherapy in Advanced Epithelial Ovarian Cancer )
Publicationinfo   1992 Jan; 024(05): 724-730.
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Abstract   Treatment response was assessed in 10 patients transfered to out institution after failure at primary cytoreductive surgery. At our institution they underwent cytoreductive surgery after induction chemotherapy. 12 patients who had residual tumor mass of over 2cm in size after primary surgery and underwent second look faparotomy after chemotherapy were used as control. The following results were obtained. 1 ) The mean age of the 10 patients was 47 years. 6 patients had FIGO stage III disease while 4 patients had FIGO stage IV diseases. Serous cystadenocarcinoma and grade 3 was of the highest incidence. In 9 patients, the abdominal mass at primary surgery was over 5 cm in size. 5 patients underwent tissue biopsy only at other institutes. After cytoreductive surgery after undergoing 7.9 cycles(mean) of induction chemotherapy, 8 patients had no residual tumor mass, I patient had a residual tumor mass af less than 2 cm in size, and 1 patient had a residual tumor mass of 2-5 cm in size, while none had a residual tumor mass of over 5 cm in size. Clinically, complete response occured in 4 patients and partial response occured in 3 patients, while surgico-pathologically, complete response ocuured in 3 patients and partial response occured in 6 patients. The overall response rate was 90%. 2) The mean age of the l2 patients from the control group was 44.5 years. 7 patients had FIGO stage III disease and 5 patients had FIGO stage IV disease. Serous cystadenocarcinoma and grade 3 was of the highest incidence. The abdominal mass was over 5 cm in size in all cases. The patients underwent 8.5 cycles(mean) of chemotherapy and 7 patients underwent a second look laparotomy. Clinically, complete response occured in 6 patients and partial response occured in 2 patients, with a response of 80/. Surgico-pathologically, complete or partial response occured in 6 of the 7 patients that underwent a second look laparotomy.
저 자   박찬규(Tchan Kyu Park),최형민(Hyung Min Choi),김수녕(Soo Nyung Kim),김형순(Hyeong Soo Kim),김경수(Gyung Soo Kim),김정연(Jeong Yeon Kim)